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Chronic Hepatitis Delta Virus (HDV)

Chronic Hepatitis Delta Virus (HDV)

What it is

HDV, a coinfection that occurs in some people infected with the hepatitis B virus, is the most severe form of viral hepatitis due to the potential for rapid progression to liver cirrhosis, liver cancer and liver-related death.1

HDV affects approximately 230,000 people in the United States and Europe.2

Signs and Symptoms

HDV often accelerates liver damage beyond that caused by hepatitis B alone. People with HDV may experience persistent fatigue, abdominal discomfort, jaundice (yellowing of the skin or eyes), and unexplained weight loss.

Fatigue 3
Abdominal Discomfort 3
Yellow skin or eyes (jaundice) 4
Unexplained Weight Loss 5

Over time, ongoing inflammation can lead to progressive liver scarring (fibrosis), cirrhosis, and increased risk of liver failure or liver cancer, with symptoms and severity varying from person to person. 6

There are currently no approved treatments for HDV in the United States and most countries worldwide.

References

  1. Hepatitis delta: Virology, pathogenesis and treatment. Journal of Viral Hepatitis. The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis. Journal of Hepatology. https://www.sciencedirect.com/science/article/pii/S0168827820302208
  2. Data on file.
  3. Estimating the global prevalence, disease progression and clinical outcome of hepatitis delta virus infection. Journal of Infectious Diseases. https://pubmed.ncbi.nlm.nih.gov/31778167/
  4. Recent treatment advances and practical management of hepatitis D virus infection. ScienceDirect. https://www.sciencedirect.com/science/article/pii/S1470211824045895
  5. Hepatitis D: Symptoms, diagnosis and treatment | BMJ Best Practice. https://bestpractice.bmj.com/topics/en-gb/3000320
  6. Hepatitis D: A Review. JAMA. https://jamanetwork.com/journals/jama/fullarticle/2811969
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