Senior Director / Director, Commercial Supply Chain Partner Markets

Mirum focuses on finding and developing drugs for difficult-to-treat liver diseases. Our programs are focused on cholestatic liver disease in children and adults.  Our drug candidates, maralixibat and volixibat, target the bile acid accumulation from cholestasis, and we believe our approach can address the underlying cause of symptoms, liver damage, and clinical outcomes. Our goal is to give families their lives back.


Provide leadership and support in the planning, development, and execution of commercial supply chain activities for Partner and Distributor markets.  The successful candidate will demonstrate leadership ability, end-to-end commercial supply chain expertise, be able to work independently and enjoy working in a dynamic, complex, fast-paced environment during a period of significant growth.


  • Direct supply chain management activities for Partner and Distributor markets
  • Partner with VP Supply Chain to develop a global S&OP planning process to ensure we are meeting worldwide demand for both early access programs and commercial readiness.  Align production requirements internally with CMC, Quality, and Supply Chain counterparts and own communication of supply to partner and distributor markets
  • Co-lead negotiation efforts for major contracts and global distribution agreements
  • Good knowledge of global regulatory requirements that may impact Mirum’s supply chain and ability to supply ex-US markets
  • Optimize 3PL global footprint for worldwide distribution
  • Partner with VP Supply Chain to develop business continuity models to mitigate the end-to-end supply chain for Mirum’s products
  • Manage POs, Change Orders and spend for CPOs and 3PLs
  • Develop associated SOPs and WIs for inventory management, distribution, and recalls
  • Oversee trade compliance for global commercial product distribution for full compliance with all local and international requirements and regulations
  • Initiate and manage high value intercontinental shipments
  • Support new products and product improvements (potential combination products) by participating in cross functional core teams, including responsibility for infrastructure and documentation



  • B.A./B.S. preferred
  • 12+ years of experience in pharmaceutical operations and supplier management functions
  • Must have previous experience with pharmaceutical, commercial supply operations, preferable in a supply company
  • Successful vendor management experience
  • Experience in a biotech or biopharma environment
  • Proven understanding of global pharmaceutical distribution requirements
  • Proven experience of global pharmaceutical regulatory / registration requirements
  • Experience establishing pharmaceutical supply chain systems and networks are essential
  • Experience with cold chain would be beneficial


Knowledge, Skills, and Abilities:

  • Proven ability to lead complex contractual negotiations with a deep understanding of financial considerations when it comes to procurement and supply chain
  • Understands and wants to work in a small company environment and is a “doer”
  • Proactive, shows good judgement, anticipates future consequences, and can make decisions decisively in the face of ambiguity
  • Can apply knowledge to new situations
  • Creates a sense of partnership with vendors but can be direct when needed
  • Can work collaboratively maintaining the ‘team spirit’ with other functional areas
  • Thinks outside the box and can come up with creative solutions when faced with challenges.  Ability to flex and adapt to complex and changing strategy/deliverables
  • Can prioritize (and quickly re-prioritize as needed) and multi-task
  • Not afraid to speak up when there is a better way to do something
  • Has integrity, honesty, conscientiousness, is team-oriented and willing to jump in wherever needed and organized


To apply, please send your resume to